Life Science Buffers

Balanced salt solutions and powders used for molecular, protein, nucleic acid, and cell biology applications including cell culture, electrophoresis, ELISA, and chromatography processes; available in a variety of formulations and grades.

Buffer solutions serve to keep pH (acidity or alkalinity) nearly constant in a variety of chemical and biological applications. For example, a bicarbonate buffer helps maintain the pH of blood, a buffered saline maintains cellular contents at a consistent pH level, and buffers help maintain a narrow pH range for enzymes to function correctly.

Most biological samples used in research are kept at a pH of about 7.4. Common biological buffers used for tissue culture include Dulbeccos phosphate buffered saline (PBS), Tris base, HEPES, MOPS, PIPES, and other formulations developed for specific cell lines or applications. Most buffers used in cell culture are also DNase-, RNase-, and protease-free.

The choice of buffer for a particular biological reaction or site depends on several factors:

Temperature
Desired or target pH
Buffer toxicity (to the system)
Buffer interactions with other system components

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166 – 180 of 3,331 results

166

Thermo Scientific Chemicals CAPS, 0.5M buffer soln., pH 10.5

CAS: 1135-40-6 Molecular Formula: C9H19NO3S Molecular Weight (g/mol): 221.32 MDL Number: MFCD00003837 InChI Key: PJWWRFATQTVXHA-UHFFFAOYSA-N IUPAC Name: 3-(cyclohexylamino)propane-1-sulfonic acid SMILES: OS(=O)(=O)CCCNC1CCCCC1

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Specifications

CAS	1135-40-6
Molecular Weight (g/mol)	221.32
MDL Number	MFCD00003837
SMILES	OS(=O)(=O)CCCNC1CCCCC1
IUPAC Name	3-(cyclohexylamino)propane-1-sulfonic acid
InChI Key	PJWWRFATQTVXHA-UHFFFAOYSA-N
Molecular Formula	C9H19NO3S

167

Tricine, 98+%

CAS: 4-1-5704 Molecular Formula: C6H13NO5 Molecular Weight (g/mol): 179.17 MDL Number: MFCD00004277 InChI Key: SEQKRHFRPICQDD-UHFFFAOYSA-N Synonym: N-(Trishydroxymethylmethyl)glycine PubChem CID: 79784 ChEBI: CHEBI:39063 IUPAC Name: 2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid SMILES: C(C(=O)O)NC(CO)(CO)CO

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Specifications

PubChem CID	79784
CAS	4-1-5704
Molecular Weight (g/mol)	179.17
ChEBI	CHEBI:39063
MDL Number	MFCD00004277
SMILES	C(C(=O)O)NC(CO)(CO)CO
Synonym	N-(Trishydroxymethylmethyl)glycine
IUPAC Name	2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid
InChI Key	SEQKRHFRPICQDD-UHFFFAOYSA-N
Molecular Formula	C6H13NO5

168

Thermo Scientific Chemicals EPPS, 0.2M buffer soln., pH 8.0

CAS: 16052-06-5 Molecular Formula: C9H20N2O4S Molecular Weight (g/mol): 252.329 MDL Number: MFCD00006160 InChI Key: OWXMKDGYPWMGEB-UHFFFAOYSA-N Synonym: HEPPS PubChem CID: 85255 ChEBI: CHEBI:42298 IUPAC Name: 3-[4-(2-hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid SMILES: C1CN(CCN1CCCS(=O)(=O)O)CCO

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Specifications

PubChem CID	85255
CAS	16052-06-5
Molecular Weight (g/mol)	252.329
ChEBI	CHEBI:42298
MDL Number	MFCD00006160
SMILES	C1CN(CCN1CCCS(=O)(=O)O)CCO
Synonym	HEPPS
IUPAC Name	3-[4-(2-hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
InChI Key	OWXMKDGYPWMGEB-UHFFFAOYSA-N
Molecular Formula	C9H20N2O4S

169

Thermo Scientific Chemicals CAPS, 0.5M buffer soln., pH 10.0

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Specifications

CAS	1135-40-6
Molecular Weight (g/mol)	221.32
MDL Number	MFCD00003837
SMILES	OS(=O)(=O)CCCNC1CCCCC1
IUPAC Name	3-(cyclohexylamino)propane-1-sulfonic acid
InChI Key	PJWWRFATQTVXHA-UHFFFAOYSA-N
Molecular Formula	C9H19NO3S

170

HEPES, ≥99% (Dry Basis), Ultrapure

CAS: 7365-45-9 Molecular Formula: C8H18N2O4S Molecular Weight (g/mol): 238.30 MDL Number: MFCD00006158 InChI Key: JKMHFZQWWAIEOD-UHFFFAOYSA-N Synonym: N-[2-Hydroxyethyl]piperazine-N'-[2-Ethanesulfonic acid] PubChem CID: 23831 ChEBI: CHEBI:42334 IUPAC Name: 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid SMILES: OCCN1CCN(CCS(O)(=O)=O)CC1

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Specifications

PubChem CID	23831
CAS	7365-45-9
Molecular Weight (g/mol)	238.30
ChEBI	CHEBI:42334
MDL Number	MFCD00006158
SMILES	OCCN1CCN(CCS(O)(=O)=O)CC1
Synonym	N-[2-Hydroxyethyl]piperazine-N'-[2-Ethanesulfonic acid]
IUPAC Name	2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
InChI Key	JKMHFZQWWAIEOD-UHFFFAOYSA-N
Molecular Formula	C8H18N2O4S

171

Thermo Scientific Chemicals Phosphate-buffered saline (PBS, 10X), RNase free

Helps to maintain a constant pH

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Specifications

Physical Form	Liquid
Chemical Name or Material	Phosphate Buffered Saline (PBS)
Recommended Storage	Ambient temperatures
Concentration	10 X

172

Thermo Scientific Chemicals PIPES, 1.0M buffer soln., pH 6.8

CAS: 5625-37-6 Molecular Formula: C8H18N2O6S2 Molecular Weight (g/mol): 302.36 MDL Number: MFCD00006159 InChI Key: IHPYMWDTONKSCO-UHFFFAOYSA-N PubChem CID: 79723 ChEBI: CHEBI:44933 IUPAC Name: 2-[4-(2-sulfoethyl)piperazin-1-yl]ethanesulfonic acid SMILES: C1CN(CCN1CCS(=O)(=O)O)CCS(=O)(=O)O

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Specifications

PubChem CID	79723
CAS	5625-37-6
Molecular Weight (g/mol)	302.36
ChEBI	CHEBI:44933
MDL Number	MFCD00006159
SMILES	C1CN(CCN1CCS(=O)(=O)O)CCS(=O)(=O)O
IUPAC Name	2-[4-(2-sulfoethyl)piperazin-1-yl]ethanesulfonic acid
InChI Key	IHPYMWDTONKSCO-UHFFFAOYSA-N
Molecular Formula	C8H18N2O6S2

173

Thermo Scientific Chemicals Phosphate-buffered saline (DPBS, 1X), Dulbecco's formula

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Specifications

Packaging	Plastic bottle
Physical Form	Liquid
Recommended Storage	Ambient temperatures

174

Thermo Scientific Chemicals BES, 99+%, for biochemistry

CAS: 10191-18-1 Molecular Formula: C6H15NO5S Molecular Weight (g/mol): 213.25 MDL Number: MFCD00007533 InChI Key: AJTVSSFTXWNIRG-UHFFFAOYSA-N Synonym: N, N-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid PubChem CID: 73243 ChEBI: CHEBI:39045 SMILES: OCCN(CCO)CCS(O)(=O)=O

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Specifications

PubChem CID	73243
CAS	10191-18-1
Molecular Weight (g/mol)	213.25
ChEBI	CHEBI:39045
MDL Number	MFCD00007533
SMILES	OCCN(CCO)CCS(O)(=O)=O
Synonym	N, N-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid
InChI Key	AJTVSSFTXWNIRG-UHFFFAOYSA-N
Molecular Formula	C6H15NO5S

175

Thermo Scientific Chemicals Potassium phosphate, 0.5M buffer soln., pH 7.0

CAS: 7778-77-0 Molecular Formula: H2KO4P Molecular Weight (g/mol): 136.08 MDL Number: MFCD00011401 MFCD00147253 InChI Key: GNSKLFRGEWLPPA-UHFFFAOYSA-M IUPAC Name: potassium dihydrogen phosphate SMILES: [K+].OP(O)([O-])=O

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Specifications

CAS	7778-77-0
Molecular Weight (g/mol)	136.08
MDL Number	MFCD00011401 MFCD00147253
SMILES	[K+].OP(O)([O-])=O
IUPAC Name	potassium dihydrogen phosphate
InChI Key	GNSKLFRGEWLPPA-UHFFFAOYSA-M
Molecular Formula	H2KO4P

176

Thermo Scientific Chemicals CAPS, 99%, for biochemistry

CAS: 1135-40-6 Molecular Formula: C9H19NO3S Molecular Weight (g/mol): 221.32 MDL Number: MFCD00003837 InChI Key: PJWWRFATQTVXHA-UHFFFAOYSA-N Synonym: 3-Cyclohexylamino-1-propanesulfonic acid PubChem CID: 70815 IUPAC Name: 3-(cyclohexylamino)propane-1-sulfonic acid SMILES: OS(=O)(=O)CCCNC1CCCCC1

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Specifications

PubChem CID	70815
CAS	1135-40-6
Molecular Weight (g/mol)	221.32
MDL Number	MFCD00003837
SMILES	OS(=O)(=O)CCCNC1CCCCC1
Synonym	3-Cyclohexylamino-1-propanesulfonic acid
IUPAC Name	3-(cyclohexylamino)propane-1-sulfonic acid
InChI Key	PJWWRFATQTVXHA-UHFFFAOYSA-N
Molecular Formula	C9H19NO3S

177

Thermo Scientific Chemicals TRIS, 1.0M buffer soln., pH 8.0, 0.2 micron filtered

CAS: 77-86-1 Molecular Formula: C4H11NO3 Molecular Weight (g/mol): 121.136 MDL Number: MFCD00004679 InChI Key: LENZDBCJOHFCAS-UHFFFAOYSA-N PubChem CID: 6503 ChEBI: CHEBI:9754 IUPAC Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol SMILES: C(C(CO)(CO)N)O

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Specifications

PubChem CID	6503
CAS	77-86-1
Molecular Weight (g/mol)	121.136
ChEBI	CHEBI:9754
MDL Number	MFCD00004679
SMILES	C(C(CO)(CO)N)O
IUPAC Name	2-amino-2-(hydroxymethyl)propane-1,3-diol
InChI Key	LENZDBCJOHFCAS-UHFFFAOYSA-N
Molecular Formula	C4H11NO3

178

Tris, MP Biomedicals™

CAS: 77-86-1 Molecular Formula: C4H11NO3 Molecular Weight (g/mol): 121.136 InChI Key: LENZDBCJOHFCAS-UHFFFAOYSA-N Synonym: 2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Trometamol, Tromethamine, Tris-[hydroxymethyl]amino-methane PubChem CID: 6503 ChEBI: CHEBI:9754 IUPAC Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol SMILES: C(C(CO)(CO)N)O

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Specifications

PubChem CID	6503
CAS	77-86-1
Molecular Weight (g/mol)	121.136
ChEBI	CHEBI:9754
SMILES	C(C(CO)(CO)N)O
Synonym	2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Trometamol, Tromethamine, Tris-[hydroxymethyl]amino-methane
IUPAC Name	2-amino-2-(hydroxymethyl)propane-1,3-diol
InChI Key	LENZDBCJOHFCAS-UHFFFAOYSA-N
Molecular Formula	C4H11NO3

179

Thermo Scientific Chemicals Tris-HCl, 0.5M buffer soln., pH 7.4, low endotoxin

CAS: 1185-53-1 Molecular Formula: C4H12ClNO3 Molecular Weight (g/mol): 157.594 MDL Number: MFCD00012590 InChI Key: QKNYBSVHEMOAJP-UHFFFAOYSA-N PubChem CID: 93573 IUPAC Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydrochloride SMILES: C(C(CO)(CO)N)O.Cl

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Specifications

PubChem CID	93573
CAS	1185-53-1
Molecular Weight (g/mol)	157.594
MDL Number	MFCD00012590
SMILES	C(C(CO)(CO)N)O.Cl
IUPAC Name	2-amino-2-(hydroxymethyl)propane-1,3-diol;hydrochloride
InChI Key	QKNYBSVHEMOAJP-UHFFFAOYSA-N
Molecular Formula	C4H12ClNO3

180

Thermo Scientific Chemicals TAPS, 99+%, for biochemistry

CAS: 29915-38-6 Molecular Formula: C7H17NO6S Molecular Weight (g/mol): 243.27 MDL Number: MFCD00007538 InChI Key: YNLCVAQJIKOXER-UHFFFAOYSA-N Synonym: 3-[Tris(hydroxymethyl)methylamino]-1-propanesulfonic acid PubChem CID: 121591 IUPAC Name: 3-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]propane-1-sulfonic acid SMILES: OCC(CO)(CO)NCCCS(O)(=O)=O

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Specifications

PubChem CID	121591
CAS	29915-38-6
Molecular Weight (g/mol)	243.27
MDL Number	MFCD00007538
SMILES	OCC(CO)(CO)NCCCS(O)(=O)=O
Synonym	3-[Tris(hydroxymethyl)methylamino]-1-propanesulfonic acid
IUPAC Name	3-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]propane-1-sulfonic acid
InChI Key	YNLCVAQJIKOXER-UHFFFAOYSA-N
Molecular Formula	C7H17NO6S

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